Manifold Discord Channel: Live Q&A with Steve — Episode #90
Manifold has its own Discord channel! https://discord.gg/dvcHS6NX
The purpose of the channel is to create a community of listeners with shared interests. It developed from a series of in-person meetups with Steve in cities like SF, NYC, Singapore, Beijing, Shanghai.
This episode is a recorded Q&A with Discord participants.
Chapter markers:
00:00 Introduction and Purpose of Manifold Live Q&A
02:36 Genomics and Predictive Genetics
09:28 Trump Administration and Political Commentary
29:42 Missile Defense Systems: Historical Challenges and Modern Realities
36:48 Failures and Cover-Ups in Missile Defense
45:23 Developing Intellectual Taste and Productivity Tips
Links related to Q&A:
Best genomic predictor for cognitive ability
https://x.com/hsu_steve/status/1936401098345980207
Ted Postol on missile defense
China-US comparisons:
https://www.manifold1.com/episodes/letter-from-beijing-with-han-feizi-72
https://www.manifold1.com/episodes/letter-from-shanghai-reflections-on-china-in-2024-73
https://x.com/hsu_steve/status/1934216476560388250
Sputnik moment:
On genome engineering: instead of editing, do 46x whole-chromosome selection from sperm. Chromosome transfer in human cells, even two chromosomes in mice has been done. The sperm might come from edited tissue culture, but very high selection ratios are possible from natural sperm, too. If the subject is DNA sequenced, fluorescent tags for their less-desirable alleles on a chromosome can be found, all chromosomes of that type in the semen with those alleles will light up, allowing separating the others of that type with good genes by electrophoresis. This could allow elimination of genetic load in one generation, with very high effective selection factors raised to the power of the number of chromosomes thus selected. Could be of agricultural value before potential human use.
hi steve, discord link says "Invite Invalid"